MTOR and hepatocellular carcinoma: Moreover, the hyperactivation of the PI3K/AKT/mTOR and the RAS/RAF/ERK/MAPK pathways and the overexpression of growth factors (e.g., fibroblast growth factor (FGF)) combined with the overactivation of processes like angiogenesis and epithelial to mesenchymal transition (EMT) are the main culprits in the tumorigeneses of HCC (Lamarca et al., 2016).