CDK4 and cancer: Both in vitro and in vivo studies have consistently confirmed the anti-cancer potential of fucoidan via the inhibition of angiogenesis, induction of cell cycle arrest and apoptosis (Aisa et al., 2005; Zhang et al., 2011; Atashrazm et al., 2015) and down regulation of CDK4, cyclin D1 and cyclin D2 in cancer cells (Banafa et al., 2013; Boo et al., 2013) [reviewed in more details in (Atashrazm et al., 2015) and (Jin et al., 2022)].