Another group’s study showed that low-dose radiation-induced exosomal circ-METRN played an oncogenic role in glioblastoma progression and radioresistance through the miR-4709-3p/GRB14/PDGFRα pathway (Wang et al., 2021b), providing novel mechanistic insights into the potential roles of exosomal circRNAs as therapeutic targets in glioblastoma. This evidence concerns the gene METRN and glioblastoma.