Biological enrichment assessment depicted that FADD-regulated genes were primarily enriched in the replication of DNA that is DNA-dependent (GO:0006261), regulation of sister chromatid segregation (GO:0033045), DNA replication (GO:0006260), sister chromatid segregation (GO:0000819), condensed chromosome (GO:0000793), heterochromatin (GO:0000792), centromeric region (GO:0000775), chromosome, chromosomal region (GO:0098687), Prion disease (hsa05020), Cell cycle (hsa04110), apoptosis (hsa04210) and Alzheimer disease (hsa05010) (Figure 6G). This evidence concerns the gene FADD and early-onset autosomal dominant Alzheimer disease.