PAK7 mutations were found to be associated with tumor mutation burden, neoantigen load, copy number variation, CD8+ TILs, mutation rate in the DDR-related pathways, suggesting that PAK7 mutations could be a helpful biomarker for prediction of the immunotherapy efficacy in NSCLC patients (Zeng et al., 2022). This evidence concerns the gene PAK5 and non-small cell lung carcinoma.