After infection, LPS molecules in pathogens are recognized and regulated by lipopolysaccharide binding protein (LBP)/CD14 in the cell membrane to form the LPS-LBP complex, which binds to CD14/TLRs receptors on the cell surface to induce tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and other cytokines, resulting in inflammation (Bryant et al., 2010). Here, TNF is linked to infection.