Chen et al. (2017) reported the inhibitory effect of celastrol on a variety of downstream inflammatory factors induced by IL-1β. Similarly, Liu et al. (2019) reported that glycyrrhizic acid could attenuate IL-1β-induced inflammation by inhibiting the high-mobility group box-1 gene. Fucoidan, a polysaccharide extracted from algae, has also been shown to inhibit inflammation in IDD (Yu et al., 2022). Here, IL1B is linked to intervertebral disk degenerative disorder.