In the imiquimod (IMQ)-induced murine model of psoriasis-form dermatitis, TRPV1 gene knockout resulted in a reduction in the infiltration of CD45+ leukocytes, mast cells and CD3+ T, accompanied by a significant decrease in the expression levels of inflammatory cytokines (IL-1β, IL-6, IL-23 and S100A8) in the skin lesions of (61). The gene discussed is TRPV1; the disease is psoriasis.