In general, the activation of TRPV1 stimulated the sensory neurons C fibers to release vasoactive peptides, such as CGRP and SP, leading to vasomotor dysfunction, and high neurovascular reactivity manifesting as paroxysmal flushing, persistent erythema and telangiectasia (Aubdool and Brain, 2011). The gene discussed is CALCA; the disease is Erythema.