The high-throughput proteomics analysis revealed differential expressions of Acsl1, Plin1, Dbil5, Plin4, Col12a1, Col1a1, Col5a3, Col1a2, and Dcn, which are associated with the PPAR signaling pathway, protein digestion and absorption, and the protein glycan pathway in cancer. This evidence concerns the gene COL5A3 and cancer.