PLIN1 and Other metabolic disease: The results of the present study suggest that GTW may downregulate the expression of the PPARγ, Acsl1, and Plin1 genes, causing the metabolic disorder of fatty acid, inhibiting energy metabolism in the testis, aggravating the oxidative stress of cells, and leading to the atrophy of the seminiferous tubule and the decrease in sperm number and vitality.