CD274 and neoplasm: Liu et al. (2021) revealed that AS-IV (10 μg/mL) inhibited angiogenesis in gastric cancer cells (SGC7901 and MGC803) by regulating microRNA-195-5p-mediated PD-L1. AS-IV can also significantly reduce the expressions of VEGF, FGF2, HGF, TF, and FVII and inhibit the growth and angiogenesis of orthotopic transplanted tumor in nude mice (Zhang et al., 2017).