Liu et al. (2021) revealed that AS-IV (10 μg/mL) inhibited angiogenesis in gastric cancer cells (SGC7901 and MGC803) by regulating microRNA-195-5p-mediated PD-L1. AS-IV can also significantly reduce the expressions of VEGF, FGF2, HGF, TF, and FVII and inhibit the growth and angiogenesis of orthotopic transplanted tumor in nude mice (Zhang et al., 2017). The gene discussed is HGF; the disease is neoplasm.