Furthermore, DHA also inhibited the elevation in p-IKKα/IκBα and NF-κB p65 in vivo and in vitro, meanwhile inhibiting the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1 (Li and zhou, 2019) significantly reduced the TLR4 level and the activation of MyD88, IRAK4, and NF-κB, and delayed the progression of LN (Diao et al., 2019). This evidence concerns the gene NFKB1 and lobular neoplasia.