An increase in the levels of proapoptotic proteins Cytochrome C (Cyt C), Caspase-3, and cleaved Caspase-3 was observed in HT22 cells after Aβ injury as well in brain tissue of mice with SCOP-induced cognitive impairment; however, these levels decreased after treatment with CK (Figure 9). Here, CASP3 is linked to Cognitive impairment.