NEK2 and infection: IFN-γ is possibly involved in the pathogenesis of IBS-D after infection (He et al., 2018); Nek2 is involved in the pathogenesis of IBS-D by activating the AKT pathway (Wan et al., 2021) pathway (Xia et al., 2021); Nde1 is involved in the pathogenesis of IBS-D by regulating the MAPK pathway (Lanctot et al., 2013) (Xia et al., 2021); Cep131 (Wang et al., 2020), Tgfb2 (Guo et al., 2016), Qsox1 (Geng et al., 2020) mediate IBS-D pathogenesis through activation of PI3K/AKT pathway as well as other factors (Guo et al., 2020b).