Figure 3B showed that normal histology was observed in the ND group, and IH caused no overt pathological change in the presence of ND. Compared with mice in the ND group, significant pathological findings such as marked steatosis, ballooning hepatocytes, lobular inflammation, and NAS were observed in the HFHFD group. IH exposure alleviated these morphological changes and decreased NAS score in the HFHFD feeding mice. Similarly, elevated transaminases including ALT and AST in HFHFD mice were significantly decreased by IH (Figure 3C). This evidence concerns the gene GPT and steatosis.