It was further analyzed for ascertaining the correlation between the change in B-cell subset frequencies, the B-cell activation markers at an early stage, and the SLE disease activity markers (including SLEDAI-2K, anti-dsDNA, IgG, C3, C4, proteinuria, ESR, and CRP), and no correlation was found. This evidence concerns the gene C4A and systemic lupus erythematosus.