It has been postulated that, incretins might exert neuropsychiatric effects given the presence of GLP-1 receptors in the central nervous system; stimulation of GLP-1 receptors has shown effects on mitochondrial functions, neuroinflammation, synaptic plasticity, learning and memory, serotonin turnover, serotonin-receptor expression in the amygdala and central dopamine levels, in multiple experimental models of both neurological diseases and depression (athauda and Foltynie, 2016; Athauda and Foltynie, 2016; Kim et al., 2020; van Bloemendaal et al., 2014). Here, GLP1R is linked to major depressive disorder.