Empirical insights showed that it ameliorates stress-induced depression-like behaviours through the enhancement of BDNF expression via AMPK/CREB-mediated histone acetylation (Fang et al., 2020) and it has been shown to elicit marked anti-inflammatory, antioxidant, and neuroprotective activities and to improve memory and learning functions in rats (Pintana et al., 2012; Shivavedi et al., 2017). Here, CREB1 is linked to major depressive disorder.