In agreement with this finding, studies have reported an association of a functional polymorphism in the promoter region of the MPO gene (rs2333227, G-463A) with cognitive function and risk of Alzheimer’s disease (Crawford et al., 2001; Combarros et al., 2002; Pope et al., 2006; Talarowska et al., 2015). Here, MPO is linked to early-onset autosomal dominant Alzheimer disease.