Alcohol intake accounts for 13.3% of cg06690548 methylation variation at SLC7A11. Although high alcohol intake (greater than two drinks/day) was associated with increased TG (Foerster et al., 2009; Klop et al., 2013), other studies have indicated that alcohol intake is associated with increased HDL-C and decreased TG, and increased risk of hypertension, coronary heart disease, and myocardial infarction (Rosoff et al., 2020). Here, SLC7A11 is linked to hypertensive disorder.