A recent study demonstrated that miR-101-3p prevented retinoblastoma cell proliferation by targeting EZH2 and HDAC9 (Jin et al., 2018), prevented autophagy in endometrial cancer cells by targeting EZH2 (Wang and Liu, 2018) and inhibits invasion and metastasis in renal cell carcinoma by Targeting EZH2 (Dong et al., 2021). The gene discussed is EZH2; the disease is hereditary clear cell renal cell carcinoma.