ISG15 and viral infectious disease: Ontology terms such as defence response to virus and negative regulation of viral genome regulation were amongst the most significant and encompass genes such as IFIT1, OAS1X, IFIT5, OAS2, IL12B, ISG15, MX1, IFITM3, RSAD2, OASIY, OAS1Z, ISG20, APOBEC32, and IFITM3. Furthermore, enriched KEGG pathways were also related to viral infection with Influenza A amongst the most significant.