Granulocyte Adhesion and Diapedesis was among the statistically most significant of the canonical pathways identified by IPA and genes involved include CCL8, CD99, CLDN3, CXCL5, CXCL8, CXCL10, GNAI1, IL18, IL1R2, MMP14, PPBP, SDC3, and SELP. This pathway is involved in leukocyte migration to sites of injury or infection. The gene discussed is CLDN3; the disease is infection.