Willeit explored the potential effects of curcumin on cardiomyocyte hypertrophy, possible mechanisms of nuclear transcription factor signaling in diabetes, hyperglycemia- and insulin-induced cardiomyocyte hypertrophy, and antihypertrophic effects of curcumin in primary culture (Willeit et al., 2017). The gene discussed is INS; the disease is Hyperglycemia.