Baumeister, Julian et al. reported higher protein level of HIF1α in 32D Jak2V617F-expressing cells than Jak2WT, and identified HIF-1 target genes involved in the Warburg effect as a possible underlying mechanism in JAK2V617F-positive MPN (Baumeister et al., 2020). The gene discussed is HIF1A; the disease is myeloproliferative disorder.