TP53 and breast cancer: As we known, HGSOC is recognized by near-ubiquitous TP53 (tumor protein 53) mutation and/or BRCA1/2 (breast cancer susceptibility gene 1/2) mutation, somatic and/or germline mutations in genes involved in genome-wide copy-number variation and homologous recombination repair (Kurman and Shih Ie, 2010; Cancer Genome Atlas Research, 2011; Huang et al., 2018; Barnes et al., 2021).