AKT1 and endometrial cancer: However, existing studies have found that the pathogenesis of OCCC is similar to endometrial cancer, such as inactivation of tumor suppressor genes such as PTEN (phosphatase and tensin homologue) and ARID1A (AT-rich interactive domain 1A), activation of the PI3K/AKT/mTOR (phosphoinositide-3 kinase/protein kinase-B/mammalian) signal pathway, and high microsatellite instability (MSI) (Ueda et al., 2005; Gounaris et al., 2011; Xiao et al., 2012; Worley et al., 2015; Willis et al., 2017).