Annexin A4 (AnxA4), an important member of the annexin superfamily, binds to calcium ions and phospholipids simultaneously to regulate cell membrane permeability and cell membrane transport, mediating cell growth and apoptosis, and participating in tumor proliferation, invasion and metastasis, angiogenesis and chemotherapy resistance (Yao et al., 2016). The gene discussed is ANXA4; the disease is neoplasm.