Except for ARID1A mutation leading to the inactivation of SWI/SNF, which we discussed above, it was reported that BRG1 phosphorylation inhibited the functions of the SWI/SNF complex in chromatin activation and thus derived tumor malignancy, thereby promoting the expression of various cancer-related proteins (Kimura et al., 2021). Here, SMARCA1 is linked to cancer.