PIK3CA and central nervous system cancer: Zeng et al. discovered that overexpression of ARID1A in glioma cells reduced the expression of pAKT and pS6K and arrested the cell cycle in G1/S phase through the PI3K-AKT signaling pathway, leading to inhibition of cell proliferation and induction of apoptosis in glioma cells (Zeng et al., 2016).