Compared to the cirexo-HC group, the expression levels of ENST00000313807 (P < 0.05), NON-HSAT194388.1 (P < 0.05), and COL1A1 (P < 0.01) in the SSc-cirexo group were significantly increased, while the expression levels of hsa-miR-29a-3p (P < 0.0001), hsa-miR-29b-3p (P < 0.01), and hsa-miR-29c-3p (P < 0.01) were significantly decreased (Figure 11A). This evidence concerns the gene COL1A1 and systemic sclerosis.