COL1A1 and systemic sclerosis: Therefore, the ENST00000313807-hsa-miR-29a-3p-COL1A1 network can not only be used as a combined biomarker to diagnose SSc, but ENST00000313807 also interacts with hsa-miR-29a-3p, which interacts with COL1A1. However, whether the ENST00000313807-hsa-miR-29a-3p-COL1A1 network participates in the biological process of SSc pathogenesis through interaction, as well as the underlying mechanism, requires further study.