Therefore, ENST00000313807, NON-HSAT194388.1, COL1A1, hsa-miR-29a-3p, hsa-miR-29b-3p, and hsa-miR-29c-3p in ceRNA networks may be used as a diagnostic biomarker or therapeutic target for SSc in the future. This evidence concerns the gene COL1A1 and systemic sclerosis.