According to our study, we speculated that the ENST00000313807-hsa-miR-29a-3p-COL1A1 network in SSc plasma cirexos may interact with the high expression of Scl-70, Ro-52, CENP-B, and other specific markers in the serum of patients with SSc, thus affecting the development of SSc fibrosis. This evidence concerns the gene COL1A1 and systemic sclerosis.