Therefore, IL-10 can regulate the TLR4/NF-κB pathway in dermal fibroblasts through the IL-10 receptor (IL-10R)/STAT3 axis to reduce both ECM protein deposition and fibroblast transformation to myofibroblasts, thereby inhibiting the formation of skin scar induced by lipopolysaccharide. The gene discussed is STAT3; the disease is neoplasm.