Neutrophil adhesion, extravasation, and NETs were seen in the brain areas of Aβ deposits in 5xFAD mice. Soluble Aβ induced LFA-1 integrin expression on neutrophils (causing adhesion to BMECs) and activated ROS production. Depleting neutrophils by anti-Ly6G or inhibiting LFA-1 significantly improved cognitive performance, reduced microgliosis, and lowered the load of Aβ and phosphorylated tau in 3xTg-AD mice (121). The gene discussed is MAPT; the disease is Alzheimer disease.