These ROR1 CAR-T cells were effective against sarcoma cells as evidenced by the synthesis of high levels of IFN-γ, TNF-α, and IL-13 in cocultures with sarcoma cell lines and the ability to reduce the tumor growth in a murine osteosarcoma xenograft model (122) (Supplementary Table 1). The gene discussed is ROR1; the disease is sarcoma.