Second, 35 (17%) additional cases carried gene mutations (SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2) that were commonly associated with secondary AML (“secondary-type AML”; ref. 13), even though they did not carry myelodysplastic-related changes according to the current WHO criteria. The gene discussed is U2AF1; the disease is acute myeloid leukemia.