SMC3 and myelodysplastic syndrome: For MDS, the THAMP dataset provided evidence that the genes situated at the left end of the Pan-Myeloid Axis added independent prognostic value in adult MDS-EB beyond IPSS-R scoring, consistent with the previously reported adverse impacts of mutations in ASXL1, BCOR, BCORL1, CBL, CUX1, EP300, ETV6, EZH2, JAK2, NF1, PRPF8, PTPN11, SETBP1, SF3B1, SMC3, SRSF2, STAG2, and U2AF1 (all classified as “myeloid.gene.L” or “myeloid.gene.ML”; refs. 13, 29, 87–95).