In addition, all the gene mutations that have been previously reported to be associated with secondary AML (SRSF2, SF3B1, U2AF1, ZRSR2, ASXL1, EZH2, BCOR, or STAG2; ref. 13) were all classified as “myeloid.gene.ML” and situated at the left side of the Pan-Myeloid Axis. This evidence concerns the gene EZH2 and acute myeloid leukemia.