RUNX1 and myelodysplastic syndrome: In MDS, previous studies have reported that SF3B1 and DNMT3A mutations are associated with high platelet count (44, 45), that GATA2 mutations are associated with monocytosis (46), and that mutations in RUNX1, TP53, and NRAS are associated with severe thrombocytopenia and higher blast count (47).