APC and colon carcinoma: Next, in comparison with the selected TNKSi panel, the potential of OM-153 as an antiproliferative agent was tested in a cell growth assay in the adenomatous polyposis coli (APC)-mutated, WNT/β-catenin signaling–dependent, and TNKSi-sensitive colon carcinoma cell line COLO 320DM (7, 32, 33, 40).