AXIN2 and neoplasm: OM-153 treatment stabilized AXIN1 and AXIN2 proteins in the tumor specimen, while β-catenin protein and the WNT/β-catenin signaling target genes dickkopf WNT signaling pathway inhibitor 1 (DKK1), APC downregulated 1 (APCDD1), and NKD inhibitor of WNT signaling pathway 1 (NKD1) were dose-dependently reduced (Fig. 4D and E; Supplementary Fig. S6E).