GSEA revealed that the VEGF, TGF-BETA, WNT, JAK-STAT, and NOTCH pathways were enriched in the high-risk population (Fig. 7A); all of these pathways were involved in malignant invasion and tumor angiogenesis [[31], [32], [33], [34], [35]]. This evidence concerns the gene TGFB1 and neoplasm.