High levels of PTH are associated with bad quality of sleep and RLS in patients affected by the end-stage renal disease (4), and even in this case, surgical removal of the parathyroid glands appears to improve symptoms of RLS, hypothesizing that an imbalance between calcium and phosphate levels could be the underlying etiology of the irresistible urge to move the legs (17). This evidence concerns the gene PTH and stage 5 chronic kidney disease.