Finally, we evaluated the correlation of ammonia with the severity of liver disease (UNOS MELD [2016] score and HVPG), serum BA levels, endothelial dysfunction (vWF), markers of systemic inflammation (CRP, PCT, and IL-6) as well as liver fibrogenesis/matrix remodelling (ELF-test), and markers of hyperdynamic circulation/systemic haemodynamic impairment (mean arterial pressure [MAP], copeptin, renin, and serum sodium). This evidence concerns the gene REN and liver disorder.