FBN1 and Marfan syndrome: Compare to Marfan syndrome carrying FBN1 mutation, MV involvement is less frequent in LDS type 2: MVP was found in 21 vs. 45% of patients (P = 0.001), MR in 35 vs. 56% (p < 0.0001) and referral to MV surgery was rare in TGFBR2 patients (19).