The pathological consequence of higher galectin-2 concentrations is to induce granulocyte colony-stimulating factor (G-CSF), IL-6, monocyte chemoattractant protein-1 (MCP-1) and growth-related oncogene alpha (GROα) secretion from endothelial cells, thereby increasing the expression of endothelial cell surface adhesion molecules, and enhancing cancer cell-endothelial cell interactions, angiogenesis and tumor metastasis (61). The gene discussed is CCL2; the disease is neoplasm.