NRP1 and hepatocellular carcinoma: Although increased galectin-1 expression in HCC might inhibit fibrosis and inflammation, secreted galectin-1 promotes liver stellate cell activation and migration through clustering neuropilin-1/platelet-derived growth factor beta (NRP1/PDGFRβ) and NRP1/transforming growth factor beta receptor II (TGF-βRII) complexes (42).