Per the results of in vitro experiments, immunoblotting showed Dbait@ZIF-8, ADM@ZIF-8, and Dbait-ADM@ZIF-8 in tumor tissues in the treatment group; and the protein expression levels of γ-H2AX and PARP in tumor tissue in the [Dbait-ADM@ZIF-8]OPM treatment group were significantly higher than those in the control and RT groups. The gene discussed is H2AX; the disease is neoplasm.