Busch et al. [94] established a sepsis-induced coagulopathy (SIC) model by CLP surgery and found that genes related to NF-κB signal transduction, autophagy and lysosomal protein degradation were enriched in the hearts of sepsis wild-type mice but not in sepsis NLRP3-KO mice. The gene discussed is NFKB1; the disease is Sepsis.