TREM2 and early-onset autosomal dominant Alzheimer disease: Similarly, variants in the TREM2 (R47H, H157Y, and L211P) genes, which are closely associated with Alzheimer’s disease in the Caucasian population (Guerreiro et al., 2013; Li et al., 2021), were not replicated in Japanese descendants (Miyashita et al., 2014).