CLU and early-onset autosomal dominant Alzheimer disease: We also observed that multiple genes previously related to Alzheimer’s disease, such as CLU (Jun et al., 2010) SQSTM1 (Cuyvers et al., 2015) GPC6 (Kunkle et al., 2021), and ABCA7 (De Roeck et al., 2019), were dysregulated in brain cells deficient in UNC93A and WDR27 (Figure 3C).