SNAP25 and Cognitive impairment: This reduction of SNAP-25, SY1A, SYT1, and SYN leads to cognitive impairment and memory dysfunction, which can be reversed by an increase in SNAP-25, SY1A, SYT1, and SYN following the blockage of presynaptic N-type VGCCs with omega-agatoxin-Aa2a.