CHD8 and psychiatric disorder: Although additional details remain to be determined, our data may provide some baseline information given that little is known about (1) whether the strong male preponderance in autistic individuals with CHD8 mutations could be recapitulated in mice, (2) whether different CHD8 mutations lead to heterogeneous male–female differences in mice in a spatiotemporally differential manner, and (3) what mechanisms underlie the CHD8-related sexual dimorphism and the general sexual dimorphism widespread in ASD and neurodevelopmental and psychiatric disorders.