PIEZO1 and sickle cell disease: For example, genetic variants that disproportionately explain population-specific risk for MCHC include variants previously associated with hemoglobin concentration, including rs9399137 upstream of HBS1L and MYB in a study of sickle cell anemia (p = 5.24e-249 and β = 0.0783 in the meta-analysis),62 rs855791 in TMPRSS6 (p = 3.49e-241, β = 0.0692),63,64 and rs551118 upstream of PIEZO1 and CDT1 (p = 5.18e-100, β = −0.0451)65 (Table S9).