The present pooled analysis evaluated the potential immune‐complex‐related hypersensitivity that can occur in patients with AM who develop ADAs during long‐term administration of VA and assessed its relationship to the MAN2B1 subgroups through the monitoring of levels of ADAs, serum oligosaccharide, serum IgG, and any IRRs. The gene discussed is AGPS; the disease is acute myeloblastic leukemia with maturation.