Tumorswith low expression of SLFN11 depend on the ATR-CHK1-WEE1axis to tolerate replication stress, and inhibition of this pathway canre-sensitize tumor cells to PARPi.71SLFN11 downregulation has been recently reported in diseaseprogression on PARPi in two patients with EOC.51 Here, ATR is linked to neoplasm.