AMPKα1 has been reported to phosphorylate PDHA, driving PDHc activation and TCA cycle, enabling breast cancer cells to adapt to the metastasis microenvironment.15 Another study reported that α-KG is involved in AMPK activation in anoikis resistance that provides pro-metastatic potential in lung cancer.50 While our study implied that AMPKα2 epigenetically downregulates H3K9me2 and inhibits lung cancer metastasis via phosphorylating PHF2. This evidence concerns the gene PDHA1 and breast cancer.