PHF2 and metastatic malignant neoplasm in the lymph nodes: To further investigate the correlation of PHF2 and lung cancer metastasis, we found the proportion of PHF2 low-expression in patients with lymph node metastasis (N1-3) was significantly higher than that without metastasis (N0) and its expression also gradually declined with the lung cancer patients entering advanced stage (Supplementary Fig. 8g, h).