MAP2K1 and neoplasm: The growth rate of tumor with high expression of CRAF WT/K375A or MEK1/2 WT/2 A increased and these cells with high expression of wild-type CRAF or MEK1/2 were more sensitive to erianin compared with vector and CRAF K375A or MEK1/2 2 A groups (Fig. 6j–l).