These studies showed that indisulam functions as a PROTAC drug and induces the degradation of mRNA spliceosome RNA-binding motif protein 39 (RBM39) by promoting the interaction between the E3 ubiquitin ligase DNA damage-binding protein 1 and cullin 4 associated factor 15 and RBM39, leading to cancer cell death (Fig. 4d). The gene discussed is RBM39; the disease is cancer.