The most common adverse events were leukopenia (56.7%), anemia (56.7%), neutropenia (56.7%), alopecia (53.3%), fatigue (46.7%), elevated AST (40.0%), anorexia (36.7%), elevated ALT (36.7%), hypothyroidism (36.7%), proteinuria (36.7%) and nausea (30.0%). This evidence concerns the gene GPT and Decreased total neutrophil count.