All KPS (P = 0.048), stage of cancer (P = 0.015), varicosity (P < 0.001), COPD (P = 0.002), albumin (P = 0.006), PT (P = 0.015), Leukocyte (P = 0.006), EGFR-TKI (P < 0.001), Dexamethasone (P = 0.005), and Bevacizumab (P = 0.003) remained independent predictive factors in the multivariate logistic regression model. The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.