To assess the clinical relevance of these findings, AHCYL1 protein distribution and accumulation were analyzed by immunohistochemistry (IHC) staining in six normal tissues and 26 patient cases with non-small cell lung cancer: 20 (76.9%) corresponded to adenocarcinoma and six (23.1%) to tumors of other origins (three squamous, two neuroendocrine, and one large cell). Here, AHCYL1 is linked to adenocarcinoma.