EGFR and head and neck neoplasm: Cetuximab is one of the best targeted drugs for head and neck tumors, and its main antitumor effect is attributed to the blocking of EGFR signal[118].Gildener-Leapman et al. found that epidermal growth factor (EGFR) was overexpressed in 80%-90% of HNC cases, resulting in excessive proliferation, invasion, and angiogenesis of tumor cells [119].