Methyltransferase METTL3 in non‐alcoholic steatohepatitis (NASH) could induce the deacetylation of H3K27 and H3K9 by recruiting HDAC1/2 on the CCL2 promoter, thus inhibiting the expression of CCL2 and inhibiting the progression of NASH.55 This evidence concerns the gene HDAC1 and metabolic dysfunction-associated steatohepatitis.