EPO and pure red-cell aplasia: It aimed to collect long-term safety data of epoetin-ζ and to detect cases of epoetin-associated PRCA to determine if the incidence rate of PRCA with SC epoetin-ζ treatment in renal anemic patients was substantially below the incidence of 4.5 per 10,000 patient-years observed for epoetin-α (Eprex) in 2002 [6].