Taken together, the relevance of senescence in IPF and the fact SOC drugs are being broadly used, herein we evaluate whether SOC drugs exert senolytic or senomorphic effects and compare them to D + Q on apoptosis-resistant senescent primary human lung fibroblasts and we evaluated the types of cell death type induced after SOC drugs treatment of these lung cells. Here, UBXN11 is linked to idiopathic pulmonary fibrosis.